Question and test interoperability: introducing version 2 of the IMS QTI specification

The Question and Test Interoperability (QTI) specification describes an XML-based technical format for the coding and exchange of assessment content from individual questions through to complete tests. The specification was first published by the IMS Global Learning Consortium in June 2000 and since then an increasing number of developers have used it as a guide to implementing assessment functionality in their e-learning systems, in addition to the more established assessment tool providers who have added QTI export/import facilities to their products. In September 2003, IMS approved a project to develop version 2 of the specification, concentrating on the format of individual 'items' and the way they can be packaged and integrated into authored learning experiences based on the companion specifications known as Simple Sequencing and Learning Design. At the time of writing, a draft of version 2 is being prepared for public review and should be available for review from the IMS website two weeks before the CAA 2004 Conference. Version 2 will represent a significant step forward for the specification, addressing many of the issues that have been raised by developers and providing some powerful new capabilities based on some of the extensions to version 1 that have developed within the community. Readers are encouraged to review the public draft for detailed technical information. This paper will concentrate on the more general issues raised with version 1 of the specification and how they are being addressed. It also attempts to address some more general criticisms of technical standardization work as a whole

New technology for interactive CAL: The origami project

Origami is a three‐year EPSRC project that forms part of a general research programme on human‐computer interaction. The goal of this research is to investigate and implement new methods for human‐computer interaction, and to apply and evaluate their use. The research centres on the DigitalDesk, an ordinary desk augmented with a computer display using projection television and a video camera to monitor inputs. The DigitalDesk allows electronic and printed documents to be combined to give richer presentation and interaction possibilities than are possible with either separate medium. This paper examines the implications of such a system for CAL, and presents two prototype applications that demonstrate the possibilities

Active paper for active learning

Recent research into distance learning and the virtual campus has focused on the use of electronic documents and computer‐based demonstrations to replace or reinforce traditional learning material. We show how a computer‐augmented desk, the DigitalDesk, can provide the benefits of both paper and electronic documents using a natural interface based on real paper documents. Many electronic documents, particularly those created using the guidelines produced by the Text Encoding Initiative (TEI), include detailed semantic and linguistic information that can be used to good effect in learning material. We discuss potential uses of TEI texts, and describe one simple application that allows a student's book to become an active part of a grammar lesson when placed on the DigitalDesk. The book is integrated into an interactive point‐and‐click interface, and feedback is related to the currently visible pages of the boo

Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR

BACKGROUND: Control genes, which are often referred to as housekeeping genes, are frequently used to normalise mRNA levels between different samples. However, the expression level of these genes may vary among tissues or cells and may change under certain circumstances. Thus, the selection of housekeeping genes is critical for gene expression studies. To address this issue, 7 candidate housekeeping genes including several commonly used ones were investigated in isolated human reticulocytes. For this, a simple ΔCt approach was employed by comparing relative expression of 'pairs of genes' within each sample. On this basis, stability of the candidate housekeeping genes was ranked according to repeatability of the gene expression differences among 31 samples. RESULTS: Initial screening of the expression pattern demonstrated that 1 of the 7 genes was expressed at very low levels in reticulocytes and was excluded from further analysis. The range of expression stability of the other 6 genes was (from most stable to least stable): GAPDH (glyceraldehyde 3-phosphate dehydrogenase), SDHA (succinate dehydrogenase), HPRT1 (hypoxanthine phosphoribosyl transferase 1), HBS1L (HBS1-like protein) and AHSP (alpha haemoglobin stabilising protein), followed by B2M (beta-2-microglobulin). CONCLUSION: Using this simple approach, GAPDH was found to be the most suitable housekeeping gene for expression studies in reticulocytes while the commonly used B2M should be avoided

Minibix: Item banking with web services

The Minibix system was developed from an existing prototype item bank system in use for high-stakes testing at the University of Cambridge. The system has been developed over the last year with support from the JISC e- Learning Programme. This project has redeveloped the system based on version 2 of the IMS Question and Test Interoperability (QTI) specification and is publishing the resulting system under an open source license. In this paper, we propose a simple service model for describing the authoring, banking, test construction and delivery of assessment content. The item banking model is implemented by the Minibix system and will be demonstrated in conjunction with authoring, test construction and delivery systems developed by the sister projects: AQuRate (Kingston University) and AsDel (University of Southampton). These services, as part of a wider e-Framework, could enable tool integration on a scale suitable for interacting with large-scale item banks. Private banks are already used routinely in high-stakes summative assessment but open repositories of items for formative use are now becoming available. For example, the E3AN item bank for Electrical and Electronic Engineering or the item bank for the Physical Sciences recently announced by the HEA

The UK market for energy service contracts in 2014–2015

This paper provides an overview of the UK market for energy service contracts in 2014 and highlights the growing role of intermediaries. Using information from secondary literature and interviews, it identifies the businesses offering energy service contracts, the sectors and organisations that are purchasing those contracts, the types of contract that are available, the areas of market growth and the reasons for that growth. The paper finds that the UK market is relatively large, highly diverse, concentrated in particular sectors and types of site and overwhelmingly focused upon established technologies with high rates of return. A major driver is the emergence of procurement frameworks for energy service contracts in the public sector. These act as intermediaries between clients and contractors, thereby lowering transaction costs and facilitating learning. The market is struggling to become established in commercial offices, largely as a result of split incentives, and is unlikely to develop further in this sector without different business models, tenancy arrangements and policy initiatives. Overall, the paper concludes that energy service contracts can play an important role in the transition to a low-carbon economy, especially when supported by intermediaries, but their potential is still limited by high transaction costs

Interactions between antenatal sulfadoxine-pyrimethamine, drug-resistant Plasmodium falciparum parasites and delivery outcomes in Malawi.

BACKGROUND Sulfadoxine-pyrimethamine (SP) is used as intermittent preventive therapy in pregnancy (IPTp) for malaria in sub-Saharan Africa. The resistance marker dhps A581G has been associated with reduced IPTp-SP efficacy and enhanced morbidity in SP-recipients. METHODS We measured SP-resistance allele frequencies in Malawian women participating in a trial (www.isrctn.com/ISRCTN69800930) comparing IPTp with SP against intermittent screening by rapid diagnostic tests (ISTp). We genotyped PCR-detected parasites using deep sequencing of SP-resistance alleles. RESULTS Among 125 placental infections, A581G-bearing parasites were associated with reduced birthweight (mean difference[MD]:252g, 95% CI:46,457, p=0.017). Relative to ISTp, IPTp-SP was associated with higher birthweights in women with wildtype parasites (MD:116g, 95% CI:-40,272; p=0.142) and lower birthweights in women with A581G-bearing parasites (MD:192g, 95% CI:-264,648; p=0.385) (pinteraction=0.033). Similar associations were noted on gestational age (pinteraction=0.075). Amongst only IPTp-SP recipients, relative to women who last received SP >4 weeks before delivery, recent SP receipt was associated with lower birthweight in women with wildtype parasites (MD:118g, 95% CI:-376,139; p=0.361) and higher birthweight in women with A581G-bearing parasites (MD:783g, 95% CI:-20,1586; p=0.054) (pinteraction=0.005). CONCLUSIONS The effectiveness on birthweight of IPTp-SP is compromised by A581G-bearing parasites, but there was no evidence that the adverse effects of these parasites are exacerbated by antenatal SP

Immobilized fibrinogen activates human platelets through GPVI

GPVI, a major platelet activation receptor for collagen and fibrin, is considered as a particularly promising safe antithrombotic target. In this study, we show that human GPVI signals upon platelet adhesion to fibrinogen. Full spreading of human platelets on fibrinogen is abolished in platelets from GPVI-deficient patients suggesting that fibrinogen activates platelets through GPVI. While mouse platelets fail to spread on fibrinogen, human-GPVI-transgenic mouse platelets show full spreading and increased Ca2+ signalling through the tyrosine kinase Syk. Direct binding of fibrinogen to human GPVI was shown by surface plasmon resonance and by increased adhesion of human GPVI-transfected Rbl-2H3 cells to fibrinogen relative to mock-transfected cells. Blockade of human GPVI with the Fab of the monoclonal antibody 9O12 impairs platelet aggregation on preformed platelet aggregates in flowing blood independent of collagen and fibrin exposure. These results demonstrate that human GPVI binds to immobilized fibrinogen and show that this contributes to platelet spreading and platelet aggregation under flow

Axial Globe Position Measurement: A Prospective Multicenter Study by the International Thyroid Eye Disease Society

Identify a reproducible measure of axial globe position (AGP) for multicenter studies on patients with thyroid eye disease (TED)